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Symbol
Name
ID
Notch2
notch 2
MGI:97364
Phenotype annotations related to liver/biliary system
Darker colors indicate more annotations
Human Phenotypes
Hepatomegaly
Cirrhosis
Reduced number of intrahepatic bile ducts
Cholestasis
Cholestatic liver disease
Prolonged neonatal jaundice
Hepatocellular carcinoma
Disease(s) Associated with NOTCH2
Alagille syndrome

Mouse Phenotypes
focal hepatic necrosis
abnormal bile duct morphology
abnormal bile duct development
Availability Mouse Genotype
Notch2tm1Grid/Notch2tm1Grid
Notch2tm2Grid/Notch2tm3Grid
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Notch2tm3Grid/Notch2tm3.1Grid
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory